Abstract
3-Dimethylamino-2, 3-dihydro-1H-pyrido[3, 2, 1-k, l]phenothiazine, the compound resulting from ring-closure between the carbon in 1-or 9-position of Phenothiazine ring and the carbon in 3-position of the side chain of chlorpromazine, and allied compounds including the chloro derivatives were prepared by the reaction of 1H-pyrido[3, 2, 1-k, l]phenothiazin-3(2H)-one (III) with formamide and N- methylformamide, followed by hydrolysis or reduction. 2-Dialkylaminomethyl-1H-pyrido[3, 2, 1-k, l]phenothiazin-3(2H)-one, in which C=O links the carbon in 1-position of phenothiazine ring and the carbon in 2-position of the side chain of chlorpromazine was also synthesized by submitting (III) to Mannich reaction.
