製剤学的研究 (第6報)

ビタミンA, Dの水溶化 その2 水素添加ヒマシ油系界面活性剤による可溶化について

抄録

Solubilization of vitamins A and D has been effected by the use of surface active agents such as Tween, Myrj, and Brij, but recently it has been found that the solubilization can be effected by the use of hydrogenated castor oil polyethylene glycol ether (HCO). In this case the best active agent differs with the kind of vitamin A and D. HCO of low polymerization degree was found to be suitable for vitamin A palmitate, while that of high polymerization degree was better for vitamin A alcohol and D. Some of HCO were found to have greater range of solubilization than Tween, Myrj, or Brij. HCO derived from hydrogenated castor oil was less toxic than that derived from non-hydrogenated castor oil. Especially, HCO of high polymerization degree was less toxic than Tween. Although hemolytic action of HCO was slightly stronger than Tween, Atlas G 1295 is low toxic and therefore suitable for injection. The irritation or pain caused by injection of HCO was not different from those caused by injection of Tween, but the taste of the former was better. From these results HCO was found to be a good solubillizing agent.