YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Biological Activity of Thiamine Anhydride
Tadashi Motoyama
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JOURNAL FREE ACCESS

1957 Volume 77 Issue 11 Pages 1230-1233

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Abstract
The structure of the substance (I), m. p. 113°, obtained on the application of benzenesulfonyl chloride to thiamine in alkaline medium, was examined and it was named thiamine anhydride by presumption of its structure. Its vitamin B1 action using rats was tested and its effect was about 1/100 of thiamine hydrochloride. In vitro treatment with liver slices made the compound show slight thiamine reaction but only around 1/200. It did not return to thiamine with cysteine or Takadiastase.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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