結核菌に対する化学療法剤の研究 (第17報)

ジピリジルグアニジン誘導体の合成及び抗菌作用

抄録

Condensation of 1, 3-di(2-pyridyl)thiourea, in the presence of desulfuration agent and alcoholic solvent, with aniline, p-aminophenol, p-alkoxyphenylamines (alkyl=CH₃ to C₁₂H₂₅), sodium p-aminosalicylate, and isonicotinic acid hydrazide afforded the corresponding dipyridylguanidine derivatives. Antibacterial tests of these compounds in vitro against tubercle bacilli showed that there is no antibacterial action in compounds not possessing alkoxyl radical and that the action increased with increasing number of carbon atoms in the alkyl chain, attaining the maximum (in minimum inhibitory concentration) in the butoxyl group, becoming weaker with further increase, and the action disappearing entirely with more than eight carbon atoms.