Abstract
Optical resolution of N-methyl-15-aza-des-N-morphinan and its 3-hydroxy compound was carried out and their pharmacological activity was examined but none showed any analgesic action. Optical resolution of 1-methyl-4-benzyioctahydro-quinoline with d-tartaric acid was attempted and it was again found that the enamine underwent conversion even with tartaric acid to ketimine to undergo cyclization to a hydrophenanthrene.
