化学療法剤の研究 (第1報)
シアノ酢酸ヒドラジドについて
1957 年 77 巻 7 号 p. 796-798
詳細
1957 年 77 巻 7 号 p. 796-798
Comparative examinations were made in relation to chemical structure on the fact that cyanoacetic acid hydrazide (CAH) shows almost the same antitubercular action as that of isonicotinic acid hydrazide (INAH). Based on the facts that CAH does not effect this action by secondary intramolecular cyclization to 3-amino-2-pyrazolin-5-one, similarity of the size of the CAH molecule and its basicity to INAH, antibacterial activity lies in the acid hydrazide group in both, and that CAH is ineffective to INAH-resistant strains, it was considered that the action mechanism of CAH is approximately the same as that of INAH and that CAH is a simplified form of INAH.
