1958 年 78 巻 12 号 p. 1348-1352
Examinations were made on the structure of the side chain in the condensate (IV) obtained by reaction of diethyl 3-(ethoxycarbonylcyanomethyl) glutarate (I) and 1-dimethylamino-2-bromopropane and it was proved to be 2-dimethylaminopropyl group. During this examination, a new pyrolysis of betaine was discovered and a presumption of its mechanism was forwarded. Saponification of (IV) and low-pressure concentration of its product as a hydrochloric acid solution was found to effect facile selective decarboxylation to form glutaric acid derivatives (V). Esterification of (V) and subsequent reduction afforded ethyl 2-oxo-5-(2-dimethylaminopropyl)-4-piperidine-acetate (VII).