接触気相反応によるピリジン塩基の合成 (第10報)

2-Methyl-3-isoalkylpyridineの合成

抄録

2-Methyl-3-alkylpyridines (I) were synthesized from allyl alcohol, methyl alkyl ketone, and ammonia at 375-400°, using a catalyst of cadmium phosphate and activated Fuller's earth. The alkyls in (I) were propyl, isopropyl, butyl, sec-butyl, isobutyl, and isopentyl. (I) was also synthesized from ethyl 2-alkyl-3-aminocrotonate (III) and diethyl malonate through several steps. The reaction hardly progressed by either routes when the alkyl was isopropyl or sec-butyl, giving the objective compounds in a very low yield.