結核菌に対する化学療法剤の研究 (第12報)

p-Aminosalicylsäureester類誘導体の抗菌作用に就いて

抄録

Growth inhibition in vitro against human type tubercle bacilli H₃₇Rv was tested with alkyl and aryl esters of 4-succinyl-, 4-maleyl-, and 4-phthalyl-amidosalicylic acid. Alkyl esters, including the esters of p-aminosalicylic acid, showed only a weak activity and comparison of bacteriostatic activity was difficult and aryl esters of p-aminosalicylic acid were far stronger than the others. p-Tolyl ester and o-and p-methoxyphenyl esters of 4-phthalylamidosalicylate showed growth inhibition 6.57-12.77 times that of p-aminosalicylic acid when the ratio of molecular weights is taken into consideration.