塩基性フェニルアルキルエーテル類の合成 (第12報)

抄録

Four kinds of the known N, N-diethyl-2-(6-allyl-2-R-phenoxy) ethylamines [R: methoxy (A), methoxycarbonyl (B), propionyl (C), and phenyliminomethyl (D)] show excellent uterus contracting action, while N-2-chloroethyl-N-ethyl-2-(2-benzylphenoxy) ethylamine (E) and N, N-diethyl-2-(2-benzyl-6-chlorophenoxy) ethylamine (F) possess strong antiadrenaline action. Various kinds of N, N-dialkyl-2-(o-allylaryloxy) ethylamines (XV to XXXII) were synthesized in order to examine the variation in physiological activity on the introduction of allyl, chlorine, nitro, or amino radical, relation between allyl and chlorine, and increase of molecular weight and changes is aromaticity, based on the foregoing facts.