イソニコチン酸ヒドラジド誘導体の理化学的研究 (第7報)
イソニコチン酸ヒドラジド誘導体の水溶液中における化学平衡とその生体内における遊離イソニコチン酸ヒドラジドとの相関関係について
1958 年 78 巻 9 号 p. 1050-1054
詳細
1958 年 78 巻 9 号 p. 1050-1054
As a measure of INAH liberation in vivo, convulsion dose (CD50) by injection in normal mice was measured and this clarified the fact that CD50 is related to equilibrium constants between free radicals in aqueous solution of INAH-hydrazone. Compounds whose equilibrium is directed towards hydrazone formation are less likely to liberate INAH in vivo.
