製剤学的研究 第8報
ビタミン A, D の水溶化 その 4 ビタミン A, D の最適 HLB について
1958 年 78 巻 9 号 p. 983-988
詳細
1958 年 78 巻 9 号 p. 983-988
The kind and amount of surface-active agent required to solubilize vitamins A and D differ according to the structure and purity of the vitamins. Examinations were therefore made on the optimal hydrophil-lipophil balance (HLB) for solubilization of various preparations of vitamin A and of vitamin D2. For this purpose, mixtures of various HLB were prepared from suitable combinations of various surface-active agents (HLB of the mixture calculated from Griffin's formula), these were mixed in vitamin A or D in a ratio 1:5 to 1:10, and these mixtures were diluted with water. The optimal HLB is obtained from relationship between the transmittance of the above aqueous solution and HLB. It was thereby found that, even in two mixtures which have the same HLB, there were some differences in their properties according to the different active agents used. When two kinds of surface-active agents with greatly differing HLB are used, the range of solubilization is smaller than when agents with small difference are used. The optimal HLB for vitamin A palmitate is 14.5-15.5, that for vitamin A acetate is 15.8-16.2, and those of vitamin A alcohol and vitamin D2 are above 17.9, and these values are in parallel with their lipophilic and hydrophilic properties. In general, vitamins with higher units obtained by purification have wider range of optimal HLB, and the optimal HLB becomes higher in the case of vitamin A palmitate. This difference is the effect of impurities and the optimal HLB differs between synthetic and natural products.
