Abstract
Oxidation of thiamine anhydride with hydrogen peroxide results in formation of sulfoxide and sulfone according to reaction conditions. Biological activity of thi-amine anhydride is about 1/100 of thiamine hydrochloride and other workers re-port that biological effect of thiamine anhydride sulfoxide is approximately equal to that of thiamine hydrochloride. Biological effect of thiamine anhydride sulfone was examined, first by in vitro regeneration of the sulfone to thiamine by liver slices, cysteine hydrochloride, or Takadiastase, but the product failed to show thiamine reaction. Attempt was then made for treatment of thiamine-deficiency in a rat but the sulfone did not show any efficacy.
