立体化学の研究 第19報

dl-2-Phenyl-4,5-cyclohexanothiazolineのN-アルキル化によるdl-2-Monoalkylaminocyclohexanethiolの合成

抄録

In accordance with N-alkylation of dl-2-methyl-4, 5-cyclohexanothiazoline, alkyl iodide was applied to dl-2-phenyl-4, 5-cyclohexanothiazoline and corresponding thia-zolinium salt was obtained, which was derived to dl-2-monoalkylaminocyclohexane-thiol. The reaction did not progress in both cis and trans compounds when methyl or ethyl iodide was used, while the alkylation did not proceed with isopropyl iodide due to steric hindrance and decomposition of the iodide itself preceded. Acyl migration of N-benzoylated compound of dl-2-monoalkylaminocyclohexanethiols was also examined.