YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Studies on Aging of Pharmaceutical Preparation. III
Discoloration of Aqueous Solutions of Vitamin B6 in Acid Media
Harutada NegoroTomonori MikiShogo UedaRyuzo Okada
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1959 Volume 79 Issue 1 Pages 42-46

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Abstract
It was found that vitamin B6 is not so stable as had been believed in acid range, in the presence of oxygen, and that it colored with passage of time. The degree of coloration increased with passage of time, the rate constant of coloration was affected by pH of the solution, and the maximum rate constant of coloration in the range of pH 4.5-7 was indicated at around pH 5.5. Coloration of aqueous solution of vitamin B6 due to the hydroxyl in 3-position in its molecule and the maximum coloration at pH 5.5 is believed to be due to vitamin B6 taking a different structure in a solution of that pH.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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