フェノチアジン誘導体の合成研究 (第2報)

3-ヒドロキシピリドフェノチアジン誘導体の反応

抄録

3-Oxo-2, 3-dihydro-1H-pyrido[3, 2, 1-k, l]phenothiazine was derived to 3-alkyl (or aryl)-3-hydroxy-2, 3-dihydro-1H-pyrido[3, 2, 1-k, l]phenothiazine and further to their dimethylcarbamate. Heating of these 3-alkyl (or aryl) derivatives with hydrochloric acid in glacial acetic acid results in dehydrogenation reaction with dehydration and phenothiazinium salts were obtained. This pyrido-phenothiazinium salts produced by the action of alkali a kind of pseudo base, 1-hydroxy-3-alkyl (or aryl)-1H-pyrido-[3, 2, 1-k, l]phenothiazines and the pseudo base easily formed the ether by the action of alcohol, and regenerated the pyrido-phenothiazinium saits by the action of acid.