非水滴定の応用 (第3報)
Isoniazid-Sulfisoxazoleの分離定量法
1959 年 79 巻 4 号 p. 454-457
詳細
1959 年 79 巻 4 号 p. 454-457
Separatory determination of isonicotinic acid hydrazide (INAH) and sulfisoxazole by non-aqueous titration was attempted and a method utilizing the difference in the basicity and solubility of their acetylated compounds was established. Treatment of the mixture of these two compounds with acetic anhydride in acetic acid converts both to acetylated compounds but that of INAH is easily soluble in acid while acetylsulfisoxazole is insoluble. By separating these acetylated compounds, INAH is titrated as a base and acetylsulfisoxazole as acid with perchloric acid and sodium methoxide respectively.
