界面活性剤の製剤への応用研究 (第5報)

可溶化滴定法の研究 (II) 可溶化滴定法による非イオン性界面活性剤の研究 その1

抄録

In order to study some of the important factors contributing to solubilization system, a modified solubilization titration based on the theory of Winsor was carried out. Experimental results and considerations on the following four factors affecting surface active agents of the polyoxyethylene nonylphenyl ether type are described: (1) Concentration of the surfactant (Fig. 2), (2) nature of the solubilizate (Figs. 3, 4) (3) effect of temperature (Fig. 5), and (4) combination of surfactants (Fig. 6 and Table II). HLB values of various NP-type surfactants were calculated from Griffin's formula and these values were examined with the result obtained in the examination of the above (4) (cf. Table II). In solubilization of xylene, the optimal combination of this type of surfactants with different moles of ethylene oxide bonded to each surfactant, HLB values of a system with combinations of 7.5-9, 7.5-15, and 5-9 moles of polyoxyethylene nonylphenyl ethers gave approximately agreeing values, while the combination with 5-15 moles gave a different value. In the former three combinations, the best result was obtained from that with 7.5-9 moles. This fact has shown that HLB value, which was believed to show the characteristics of a surfactant, is not sufficient as an indicator for selection of a solubilizing system. With consideration of Winsor's theory of solubilization and the present solubilization titration, attempt was made for elucidation of this phenomenon of solubilization and it was pointed out that this titration method is an effective means in determining various factors in actual preparations.