Vitamin B₁および諸関係化合物の研究 第98報

N-(1-Methyl-2-thiocyano-4-hydroxy-1-butenyl)-N-[(2-methyl-4-amino-5-pyrimidinyl)methyl]formamide (Cyanothiamine) およびその誘導体の研究 その6

抄録

The formation of thiamine methyl sulfide from cyanothiamine by reaction with potassium hydroxide in methanol was examined and it was found that thiocyanates were able to methylate thiamine and thiophenol by the action of alkali. It was thereby assumed that in this reaction, methylation agent was formed which attacked the thiol group, which was comparatively resistant to oxidation, in thiamine and thiophenol, and the methylation agent here formed was presumed as methyl cyanate.