ピリミジン誘導体の研究 (第2報)
1,2,4-Triazolopyrimidine 類について その2
1959 年 79 巻 7 号 p. 899-903
詳細
1959 年 79 巻 7 号 p. 899-903
Boiling of 2-hydrazino-4-hydroxy-6-methylpyrimidine (I) with glacial acetic acid affords 3, 7-dimethyl-5-hydroxy-1, 2, 4-triazolo [4, 3-a] pyrimidine (VI) and its heating to above 260° converts it into 2, 5-dimethyl-7-hydroxy-1, 2, 4-triazolo [2, 3-a]pyrimidine (IX), identical with the condensation product of 3-methyl-5-amino-1, 2, 4-triazole (VIII) and acetoacetic ester. The structure of 1, 3-bis (5-amino-1, 2, 4-triazol-1-yl)-3-methyl-2-propen-1-one (XI) has been given to the condensation product obtained by reacting 5-amino-1, 2, 4-triazole (V) and acetoacetic ester in the cold, in the presence of sodium hydroxide, but this substance was proved to be the salt (XIII) of 5-methyl-7-hydroxy-1, 2, 4-triazolo [2, 3-a] pyrimidine (IV) and (V).
