スルホンアミド剤合成の研究 (第8報)
IPTD系血糖低下スルホンアミド剤の合成
1959 年 79 巻 7 号 p. 913-919
詳細
1959 年 79 巻 7 号 p. 913-919
In order to clarify the relationship between chemical structure and the hypoglycemic activity, 22 kinds of new 2-arylsulfonamido-5-alkyl-1, 3, 4-thiadiazoles were synthesized. The sulfonamides of this series which have the power to reduce blood sugar level are generally soluble in dilute alkaline carbonate, similar to N-acylated arenesulfonamides, and this nature can be utilized for their purification.
