Abstract
Growth inhibition of 8-hydroxy-1, 4-naphthoquinone derivatives was examined with bacteria and fungi. These derivatives generally showed a wide antibacterial spectrum and 2, 7-dimethyl-8-hydroxy-1, 4-naphthoquinone showed inhibition against growth of staphylococci and coli bacilli in 1, 024, 000 dilution. This was followed by the activity of 2-methyl-8-hydroxy-1, 4-naphthoquinone and juglone. For comparison of growth inhibitory action, 2-methyl-3, 8-dihydroxy-1, 4-naphthoquinone was obtained by oxidation of 2-methyl-8-hydroxy-1, 4-naphthoquinone with hydrogen peroxide in sodium carbonate solution to form an oxide and its treatment with dilute sulfuric acid.
