Lipoic Acidに関する研究 (第3報)
Alkyl 8-Alkoxy-および8-Acyloxy-6-oxoöctanoateの合成 その2
1960 年 80 巻 10 号 p. 1317-1321
詳細
1960 年 80 巻 10 号 p. 1317-1321
Heating of alkyl 8-chloro-6-oxoöctanoate (III, IV) with fatty acid results in formation of alkyl 6-oxo-7-octenoate (V, VI) and alkyl 8-acyloxy-6-oxoöctanoate (VII, VIII). Addition of a dehydrochlorination agent in this reaction was found to shorten the reaction time and increase the yield of the product. In the reaction of alkyl 8-chloro-6-oxoöctanoate (III, IV) and alcohols, ester exchange occurs due to the liberated hydrogen chloride and alkyl 8-alkoxy-6-oxoöctanoate (IX, X) is formed. Methyl 8-acetoxy-6-oxoöctanoate (VII:R′=CH3) and methyl 8-methoxy-6-oxoöctanoate (IX:R=CH3) undergo mutual transition in the presence of a suitable catalyst.
