Abstract
Sodium benzoate and salicylate have been used for a long time as a solubilization agent. It has been found that nicotinamide is a better solubilization agent than sodium nicotinate and, therefore, salicylamide derivatives and benzamides were prepared for examination as a possible solubilization agent. Salicylamides are all sparingly soluble in water and cannot be used as a solubilization agent but they showed better effect than nicotinamide when used in aqueous solution first solubilized with nicotinamide. Benzamides showed solubilization effect about equal to that of nicotinamide, but had 1.6-2.0 times the effect of nicotinamide when used for caffeine. N-2-Pyridylbenzamide hydrochloride had a very strong effect, same as the N-aryl derivatives of nicotinamide and about 4.5 times stronger solubilization effect than nicotinamide when used for adrenochrome monosemicarbazone.
