クマリン誘導体の薬品的研究 (第14報)
体温降下作用におよぼすクマリン誘導体の役割について
1960 年 80 巻 12 号 p. 1754-1759
詳細
1960 年 80 巻 12 号 p. 1754-1759
In order to elucidate the role of coumarin derivatives in effecting fall of body temperature, 2-thiocoumarin was taken up and relationship between its hypothermic action and distribution in brain tissues, chemical form in the brain, and its effect on brain tissue respiration were examined. It was found that a part of 2-thiocoumarin administered is distributed in the brain tissue as such and a part in the form of hydroxycoumarin. The sulfur atom eliminated from 2-thiocoumarin converted to organic or inorganic sulfate or entered the sulfur-containing amino acid in proteins. The amount of biological products of 2-thiocoumarin distributed in the brain tissue and the effect of lowering body temperature were in complete parallelism, the greatest hypothermic reaction being observed at the peak of distribution in the brain. 2-Thiocoumarin inhibited tissue respiration in the telencephalon, and diencephalon and midbrain.
