Abstract
Various kinds of benzoylurea derivative were synthesized and their antagonistic acitivity against pentetrazol and electric shock was examined. (I) was found to have the strongest action and, therefore, its analgesic, anticonvulsive, and hypothermic actions, potentiation against hypnotics, and its acute toxicity were examined in comparison with (II) and (III). It was suggested from these results that (I) had either the effect intermediate of (II) and (III), or had the properties of both these compounds. An effect comparable to (II) as an antiepileptics may be expected and a decrease in untoward side-effects can be made, since the toxicity of (I) is weaker than that of (II).
