Abstract
Quinoline was successfully produced in preparative yield from aniline and preformed acrolein. A glacial acetic acid solution of aniline and acrolein diacetate was added dropwise into a refluxing solution of ferric chloride and hydrochloric acid in glacial acetic acid and the mixture was refluxed for 8 hours, from which quinoline was obtained in 34.3% yield. Under similar treatment, aniline and crotonaldehyde diacetate afforded quinaldine in 50.2% yield, while aniline and methacrylaldehyde diacetate gave 3-methylquinoline in 38.7% yield.
