Abstract
In order to elucidate the relationship between chemical structure and antiviral activity of N-dodecanoyl-4-acetamidonaphthalene-1-sulfonamide (PANS-610), N-alkanoyl 4-acetamido-5, 6, 7, 8-tetrahydronaphthalene-1-sulfonamide, in which the naphthalene ring in PANS-610 had been substituted with tetralin ring, and its position isomers were prepared and their antiviral activity tested. None of these compounds prepared showed any antiviral activity in vivo and it was presumed that the tetralin ring is not effective for appearance of antiviral activity in PANS-610.
