複素環式化合物の合成研究 第61報

イミダツォイソヒノリン誘導体の合成研究 その11 8,9-Dimethoxy-3-(2-furfuryl)-および-(2-furylethyl)-5,6-dihydroimidazo [5,1-a]-isoquinolineの合成

抄録

Among the imidazoisoquinoline derivatives prepared to date, 9, 10-dimethoxy-3-(2-furyl)-5, 6-dihydroimidayo [5, 1-a] isoquinoline was found to have some activity of contracting uterus. Therefore, the same derivatives with furfuryl and furylethyl group in place of furyl in 3-position werepre pared and their pharmacological activity was examined. The compound with furylethyl group was found to have a strong uterus contracting action. This compound was prepared by application of 2-furyla-cetic acid or 3-(2-furyl) propionic acid azide to glycine ethyl ester to form the amide, derived to the azide through the hydrazide, condensed with homoveratrylamine, and submitted to isoquinoline cyclization by the usual procedure.