解熱鎮痛剤の合成研究 (第5報)
N-Antipyrinylglycine AmideのAcylationについて
1960 年 80 巻 8 号 p. 1147-1149
詳細
1960 年 80 巻 8 号 p. 1147-1149
Having some doubts about the position (N or N′) at which the acyl group is introduced in acylation of N-antipyrinyl-2-methylalanine amide (VIII), reported in the preceding paper, introduction of acyl group was examined in the most simple of the compounds with similar structure N-antipyrinylglycine amide (I). Comparison of infrared spectra of N-acetyl-N-antipyrinylglycine amide (II) and (VIII) proved that acylation of these compounds resulted in introduction of acyl group into N. Haloacylation of (I) Was also proved to give N-substituted compound.
