Abstract
Stoll and others proposed a structural formula for nocardamin but there are no reports on its synthesis. In order to confirm this structure by synthesis, 1-p-tosyl-2-azetidineëthanol was prepared earlier but attempted cleavage of its tosyl group did not materialize. Therefore, this synthetic route was changed to the Gabriel reaction of 1-p-tosyl-2-(2-bromoethyl) azetidine to form 1-p-tosyl-2-(2-p-toluenesulfonamidoethyl)-azetidine whose tosyl group was successfully cleaved by treatment with metallic sodium in liquid ammonia. This method was utilized for synthesis of 2-(2-aminoethyl) azetidine.
