Studies on the Synthesis of Pyrazinoic Acid Derivatives. I

Derivatives of Pyrazinoic Acid, Aminopyrazine, Pyrazlnohydrazlde, and Pylazinealdehyde

Abstract

Thirty-seven kinds of various new derivatives of N-substituted pyrazinamide, aminopyrazine, pyrazinoic acid hydrazide, and pyrazinealdehyde were synthesized and their antibacterial and antifungal action were tested with tubercle bacilli H₃₇RV strain, Aspergillus niger, and Penicillium notatum. All the derivatives tested showed better antituberculosis action than pyrazinamide used as the control, especially 1-isonicotinoyl-2-pyrazinoylhydrazine and pyrazinealdehyde isonicotinoylhydrazone completely stopped the growth of tubercle bacilli in a respective concentration of 0.156 and 0.0625γ/cc. Antifungal test did not reveal any better derivatives.