YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
平滑筋における薬物受容体の研究 (第1報)
シロネズミ子宮平滑筋におけるアセチルコリン, 塩化バリウムおよびオキシトシンの作用に対する拮抗
高木 敬次郎石田 行雄守時 英喜原 和子
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1961 年 81 巻 12 号 p. 1708-1712

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Concentration-action curves of acetylcholine, barium chloride, and Oxytocin were plotted and the slopes of acetylcholine and Oxytocin were n=1.0 and that of barium chloride, n=1.5. Atropine showed competitive antagonism with acetylcholine in a very low concentration (10-13 to 10-10 g./cc.), while papaverine and allied spasmolytic agents showed non-competitive antagonism with acetylcholine, barium chloride, and Oxytocin. Aspaminol, a spasmolytic agent with large degree of dissociation, showed competitive antagonism with barium chloride and it was assumed that rat uterus strip is more like intestine than trachea in behavior.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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