ステロイドの研究 第23報
麦芽酵素によるステロイドエステルの加水分解 その4 17α,19-Dihydroxyprogesteroneおよび17α-Hydroxy-19-norprogesteroneの合成
1961 年 81 巻 3 号 p. 381-384
詳細
1961 年 81 巻 3 号 p. 381-384
The acetoxyl group in 21-position of steroids is easily hydrolyzed by malt enzyme but not those in 11- and 19-positions. This selectivity was utilized for formation of 11α, 17α-dihydroxyprogesterone (VI) from 11α-hydroxylated Reichstein's substance S (I) by the route shown in Chart 1, and of 17α, 19-dihydroxyprogesterone (XIII) and 17α-hydroxy-19-norprogesterone (XV) from 19-hydroxylated Reichstein's substance S (VIII) by the route shown in Chart 2.
