キサンチン誘導体の分子化合物形成に関する研究 (第4報)

無水キサンチンメチル誘導体とフェノール, 芳香族アミン, 置換安息香酸エステル間の二成分系熱分析

抄録

Thermal analysis was carried out on 32 kinds of binary system consisting of caffeine, theophylline, or theobromine as one component and phenols, aromatic amines, or substituted benzoic acid esters as another. These methylxanthines form molecular compounds with phenols easily but does not with aromatic amines, except only nitroaniline and benzidine form binary compound with caffeine. There seemed to be no affinity with esters and only theophylline formed a molecular compound with ethyl p-aminobenzoate. It was assumed from the present series of results that two carbonyls take part in caffeine while only one takes part in theophylline and theobromine, and that the combination seemed possible with the NH group at 7-position in theophylline.