Synthesis and Antibacterial Activity of Antipyrine Derivatives. II

1-Alkylidene (or Arylidene)-4-(4-antipyrinyl)-3-thiosemicarbazide and its Related Compounds

Abstract

Fifteen kinds of new compounds of the general formula R-CH=N-NH-CSN-R′R″, where R′ is an antipyrinyl ring, were synthesized, as well as three of their cyclization product, 3-(4-antipyrinyl)-2-arylidenehydrazono-4-methyl-4-thiazolines, and their antibacterial activity was examined. These compounds in general had only a weak activity and only (XVI) showed somewhat weak growth-inhibitory action against tubercle bacilli and Stapylococcus aureus.