1962 年 82 巻 1 号 p. 50-56
Sulpyrine was decomposed with N sodium hydroxide solution and the route of its decomposition was assumed to be through 4, 4′-(N, N′-dimethylmethylenediamino)antipyrine (II) and 4-methylaminoantipyrine (I), rather than in the reverse order of (I) to (II), as assumed by Takahashi, et al. for its decomposition with dilute hydrochloric acid. Sulpyrine is decomposed quantitatively into (N-(4-antipyrinyl)-methylamino)acetonitrile (III) by potassium cyanide and it was found that (III) underwent quantitative decomposition into 1-(N-(4-antipyrinyl)methylamino)acetamidoxime (IV) by hydroxylamine and that (IV) colored reddish violet with iron (III) chloride. This reaction was utilized as a characteristic method for determination of sulpyrine.