平滑筋における薬物受容体の研究 (第5報)

血管平滑筋における可逆的拮抗剤に関する研究

抄録

Drug receptor in smooth muscles was examined with vascular strips from a guinea pig, chiefly using reversible antagonists, and following facts were revealed.
1) Sensitivity of vascular smooth muscles is similar against adrenaline, phenylephrine, histamine, and barium chloride, and a definite dose-response curve was obtained for each agent.
2) In general, following antagonistic phenomena were observed with reversible antagonists in vascular smooth muscles.
(a) Sympatholytics showed reversible, competitive antagonism against adrenaline but showed reversible, non-competitive antagonism against barium chloride and histamine.
(b) Analgesics showed reversible, non-competitive antagonism against adrenaline while anticonvulsants of strong bases, such as Benactyzine, showed a reversible, non-competitive antagonism against barium chloride and those of weak bases, such as papaverine, a reversible competitive antagonism.
(c) Vasodilators like sodium nitrite and aminophylline showed reversible, non-competitive antagonism against adrenaline.
(d) Parasympatholytics showed reversible, non-competitive antagonism against adrenaline, barium chloride, and histamine.
3) The mode of action of various anti-convulsants against vascular smooth muscles, i.e. effectivity ratio of the inhibitory action of various anti-convulsants, and antibarium action suggested that pharmacological properties of vascular smooth muscles is midway between that of tracheal smooth muscles and intestinal smooth muscles.