主薬の界面活性化の研究 (第4報)
アルキルサルフェイトの薬剤学的性質 その1 サイアミンアルキルサルフェイトのKrafft現象について
1962 年 82 巻 1 号 p. 96-101
詳細
1962 年 82 巻 1 号 p. 96-101
The Krafft point of thiamine alkylsulfates was calculated by determination of their conductivity. An increase of ca. 15° over that of sodium alkylsulfates with the same number of carbon atoms was recognized and the Krafft point was found to be affected markedly even by gegenions. The Krafft point lowered by addition of alcohols with 1-4 carbon atoms and the relationship between the degree of lowering (b) and concentration of alcohol (M) was found to be represented by equation (1). The logarithm of the degree of lowering (b) was found to increase in proportion to the increasing number of the alcohol. In thiamine hydrochloride solution of a definite concentration, there was a marked elevation and a solution above 0.03M in concentration no longer showed the Krafft phenomenon. Surface tension and critical micelle concentration (CMC) were measured at temperatures above the Krafft point and the CMC and surface tension were both found to be lower than those of sodium alkylsulfates. Since micelle formation becomes stronger in thiamine hydrochloride solution, fixation of gegenion on micelle surface was found to be the important condition for micelle formation.
