Gougerotinの化学構造の研究 その4

C物質の接触還元, Cytosine誘導体の還元に関する新知見

抄録

Catalytic reduction of the C substance over Adams platinum oxide afforded CR substance, C₁₀H₁₇O₆N₃, and one mole of ammonia. The C substance is resistant to acid hydrolysis but its reduced product, CR substance, is very labile to acids and easily undergoes hydrolysis to form tetrahydro-2 (1H)-pyrimidinone. This fact suggested the presence of a cytosine ring and the same catalytic reduction was carried out on cytosine and cytidine, from which ammonia was detected and the cytosine ring was reduced to tetrahydro-2 (1H)-pyrimidinone ring. This reaction is a new method for the reduction of cytosine derivatives and will prove to be one of useful means for determining the position of substituents in cytosine derivatives. Since cytosine was isolated by hydrolysis of C substance by boiling with nitric acid, C substance was found to be a compound having a cytosine ring and a side chain with a carboxylic acid and amino group