抄録
Photodecomposition of thioproperazine (I) was carried out by irradiation of its dimethanesulfonate in 0.72% aqueous solution with fluorescent light (twelve 20-W coolwhite light tubes, ca. 5000 luces). It was found by paper partition chromatography, using a solvent system of butanol-acetic acid-water (4:1:5) that (I) (yellow fluorescence spot, Rf 0.80) is completely decomposed in 24 hours. At the same time, a marked change took place in the ultraviolet absorption spectrum of the aqueous solution.
Ampules filled with 5% aqueous solution of the dimethanesulfonate of (I) were continuously irradiated for 72 hours and 10-[3-(4-methyl-1-piperazinyl)propyl]-2-phenothiazinesulfonic acid (II) was isolated and identified as the chief decomposition product, the yield of (II) being about 80% of the product. Photodecomposition of the dimethanesulfonate of (II) afforded 10-[3-(4-methyl-1-piperazinyl)propyl] phenothiazine.
