モノアミン酸化酵素阻害剤の研究 (第1報)
Hydrazine誘導体とα-Methylphenethylamineの作用点の異同について
1962 年 82 巻 10 号 p. 1431-1434
詳細
1962 年 82 巻 10 号 p. 1431-1434
Considering that the irreversible inhibition of α-methylphenethylhydrazine (JB-516) to monoamine oxidase is weakened in the presence of substrate tyramine, inhibitory effect of JB-516 on monoamine oxidase under various conditions, in the presence of tyramine and amphetamine, was measured manometrically. It was thereby clarified that JB-516, amphetamine, and tyramine act on the same active center and that the time of addition of the substrate has a great effect on the result of measurement of inhibitory effect of irreversible competitive inhibitor.
