カイニン酸およびその類似物質の駆虫作用に関する研究 (第2報)

虫体の酸化還元酵素に及ぼす作用 その1

抄録

Hog ascaris was found to contain a fair amount of cytochrome c and this suggests the possibility that the electron-transfer route is in a system passing through cytochrome c. Kainic acid and many of its allied substance were examined to see whether they inhibited electron transfer of hog ascaris and all were found to have such action, especially strong in kainic acid, L-proline, and many of pyrroledicarboxylic acids. Especially strong activity was found in pyrroledicarboxylic acids with isobutyl or phenyl group in 5-position of the pyrrole ring. 5-Isobutyl-4-methylpyrrol-2, 3-dicarboxylic acid (B. C. P.) and Dithiazanine were found to have stronger inhibitive action than kainic acid, vanillic acid was about equal to and N-acetylkainic acid was weaker than kainic acid. Kainic acid lactone and dihydrokainic acid had only a very weak inhibitive action. Kainic acid was found to inhibit oxidation of reduced diphosphopyridine nucleotide but not succinic acid dehydrogenase of hog ascaris.