メチルピリジン誘導体の合成 (第14報)
2,6-Lutidine 1-Oxideのオキシ誘導体と無水酢酸との反応
1962 年 82 巻 12 号 p. 1647-1649
詳細
1962 年 82 巻 12 号 p. 1647-1649
It is reported that 2, 6-lutidine 1-oxide (I) afforded 6-methyl-2-pyridinemethanol (II) and 2, 6-dimethyl-3-pyridinol (III) in the reaction with acetic anhydride and that the obtained (II) was reacted again with acetic anhydride to afforded 2, 6-pyridine-dimethanol (VI). An investigation of the reaction confirmed that (I) produced 2, 2′-ethylenebis (6-methylpyridine) (IV), besides (II) and (III), and that (V) afforded 6-methyl-picolinaldehyde (VII) and 3-hydroxy-6-methyl-2-pyridinemethanol (VIII). Further attempt of reacting 2, 6-dimethyl-3-pyridinol 1-oxide (IX) with acetic anhydride produced (VIII) and 5-hydroxy-2-methyl-2-pyridinemethanol (X).
