Abstract
Oxidation of 3-chloro-6-methoxypyridazine with hydrogen peroxide in acetic acid afforded 3-chloro-6-methoxypyridazine 1-oxide (II), 3-chloro-6 (1H)-pyridazinone (III), and 3-methoxy-6 (1H)-pyridazinone (IV). 3-Methoxy-6-pyridazinol 1-oxide (V) was obtained by heating (II) with sodium acetate in acetic acid or warming 3, 6-dimethoxy-pyridazine 1-oxide in dilute hydrochloric acid. (V) was found to exist as 1-hydroxy-3-methoxy-6 (1H)-pyridazinone from the result of ultraviolet and infrared spectra, and of alkylation.
