複素環式化合物の合成研究 第71報
パパベリン類似化合体の合成研究 その9 1-(3,5-Dihydroxyphenyl)-3-methyl-6,7-methylenedioxyisoquinolineの合成および1-(2,4-Dihydroxyphenyl) isoquinoline誘導体の合成研究補遺
1962 年 82 巻 7 号 p. 1059-1062
詳細
1962 年 82 巻 7 号 p. 1059-1062
On the synthetic study of water soluble papaverin-like compounds, 2, 4-, 3, 4- and 2, 5-dihydroxy derivatives out of the six kinds of the compounds which provide two hydroxyl groups attached to phenyl radical at 1 position were already synthesized.
In this report, acid chloride of α-resorcylic acid dibenzyl ether was condensed with α-methyl-β-methoxy-3, 4-methylenedioxyphenethylamine to the amide compound, which was cyclized with POCl3 to the isoquinoline derivatives, which was followed by the debenzylation in ethanolic hydrochloric acid to give the expected 1-(3, 5-dihydroxyphenyl)-3-methyl-6, 7-methylenedioxyisoquinoline.
