炭素-炭素二重結合への閉環反応 (第1報)
1,1-Diphenyl-ω-acylamino-1-alkeneの閉環反応
1962 年 82 巻 8 号 p. 1088-1093
詳細
1962 年 82 巻 8 号 p. 1088-1093
Pyrroline and tetrahydropyridine derivatives (IV) were synthesized by the Bischler-Napieralski cyclization with 1, 1-diphenyl-ω-acylamino-1-alkene (III). The synthesis of (IIIa, c) were carried out in the reaction of 2, 2-diphenyltetrahydrofuran (IX) by hydrobromic acid to 4-bromo-1, 1-diphenyl-1-butene (X), which gave the amine (XI) by the Gabriel reaction, followed by acylation. (IIIb, d) were obtained from acylation of the amine (XIII) which was prepared by the reduction over Raney Co from the nitrile (XII), which was derived from (X).
