Studies on the Thiazolidinecarboxylic Acid Derivatives as the Protective and Restorative Agents against Radiation Injury

Abstract

Thiazolidinecarboxylic acid derivatives were synthesized as the agents against radiation injury. Their protective and restorative effects were examined by the mortality of mice exposed to the lethal dose of X-ray. Of these derivatives, Nos. 11 and 13 were found to be protective and restorative, Nos. 1 and 16 protective, and No. 4 restorative. Nos. 4, 11, and 13 had no restorative effect on the hematologic injury of rats caused by X-ray irradiation. These substances protected the mice injected with otherwise lethal dose of sodium arsenite from death and diminished protectively the necrosis of liver caused by carbon tetrachloride.