Thiazolidinecarboxylic acid derivatives were synthesized as the agents against radiation injury. Their protective and restorative effects were examined by the mortality of mice exposed to the lethal dose of X-ray. Of these derivatives, Nos. 11 and 13 were found to be protective and restorative, Nos. 1 and 16 protective, and No. 4 restorative. Nos. 4, 11, and 13 had no restorative effect on the hematologic injury of rats caused by X-ray irradiation. These substances protected the mice injected with otherwise lethal dose of sodium arsenite from death and diminished protectively the necrosis of liver caused by carbon tetrachloride.
