水溶性, 結晶性薬剤の湿潤性に関する研究 (第8報)

抄録

Though H₃BO₃-mannit and caffeine-sodium benzoate (BNA) systems were considered to interact between the components in aqueous solution. The relation of reciprocal humidity (H)-mixing ratio of solute (y), molar ratio (x₁)-y, the activity coefficient of water (f₁)-y was the same, when interaction between the components was not taken place and equation (1) was found to be formed. CRH of caffeine-BNA by the pre-equilibrium method was the same when any interaction between the components was not taken place and any changes of the solid phase by moistning, has not been recognized. Therefore the behavior of such a mixture has been concluded to be the same as CRH of having no interaction.